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Synlett 2013; 24(9): 1160-1161
DOI: 10.1055/s-0033-1338941
DOI: 10.1055/s-0033-1338941
spotlight
Chloroacetonitrile
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
08. Mai 2013 (online)
Introduction
Chloroacetonirile is a simple organic compound with a linear chemical structure. Both ends of this molecule have a reactive group: a cyano group on one side and a chloro substituent on the other side. The nitrile can be converted into an amine, amide, amidine, etc., whereas the chloro group plays an important role in different alkylation reactions. Choloacetonitrile is known for the synthesis of heterocycles including thiophenes,[1] thiazoles[2] and thiazolo[3,2-b][1,2,4]triazoles.[3] Chloroacetonitrile is commercially available and can be synthesized by dehydration of chloroacetamide with phosphorous pentoxide.[4]
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