Asymmetric Henry Reaction Catalyzed by a Chiral Dinuclear Nickel Complex

Abstract

Several chiral polyfunctional ligands were conveniently synthesized from l-amino acids and used to prepare the dinuclear complex in situ. A novel bimetallic catalyst containing dinuclear nickel was developed and applied to the asymmetric Henry reaction. With the assistance of N-methylmorpholine, good enantio­selectivities (up to 91% ee) and moderate yields (up to 72%) were obtained for aryl, heteroaryl, and aliphatic aldehydes. The pathway was air tolerant and easily manipulated, and the reagents were readily available.

Key words

asymmetric catalysis - bimetallic catalyst - nickel - Henry reaction - nitroaldol reaction

• References


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