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Synlett 2013; 24(13): 1702-1706
DOI: 10.1055/s-0033-1339310
DOI: 10.1055/s-0033-1339310
letter
Antimony(V) Chloride as an Efficient Reagent for Deprotection of Methyl Ethers
Weitere Informationen
Publikationsverlauf
Received: 21. Mai 2013
Accepted after revision: 29. Mai 2013
Publikationsdatum:
16. Juli 2013 (online)
![](https://www.thieme-connect.de/media/synlett/201313/lookinside/thumbnails/10.1055-s-0033-1339310-1.jpg)
Abstract
This paper proposes a new and efficient method for the deprotection of methyl ethers using antimony pentachloride at ambient temperature. The procedure described here is a facile and practical method for the removal of the methyl group from aryl and benzyl methyl ethers. High selectivity was observed for the removal of the methyl group from dimethoxyarenes. The notable advantages of this protocol are mild reaction conditions, high yields, and the facility of workup procedure. The mechanism of the ether cleavage is proposed to explain this new reaction.
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