Synthesis 2013; 45(18): 2545-2550
DOI: 10.1055/s-0033-1339377
paper
© Georg Thieme Verlag Stuttgart · New York

An Efficient and Convenient Procedure for the One-Pot Synthesis of α-Aminophosphonates from Aryl Azides under Solvent-Free Conditions

Ya-Qin Yu*
Key Laboratory for Water Environment and Resources, Tianjin Normal University, Tianjin 300387, P. R. of China   Fax: +86(22)23766256   Email: yuyaqin@mail.tjnu.edu.cn
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Publication History

Received: 23 April 2013

Accepted after revision: 18 June 2013

Publication Date:
30 July 2013 (online)


Abstract

A novel and simple approach to the multicomponent one-pot reaction of aldehydes, diethyl phosphite, and azides to form α-aminophosphonates under solvent-free conditions at room temperature has been developed. In the presence of iodine and iron, aryl azides were, for the first time, used as substrates for the synthesis of α-aminophosphonates. The reactions were completed within 5 minutes to 12 hours and afforded the corresponding products in good yields.

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