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Synthesis 2013; 45(22): 3125-3130
DOI: 10.1055/s-0033-1339672
DOI: 10.1055/s-0033-1339672
paper
Facile Synthesis of 2-Fluoro-1,3-dicarbonyl Compounds with Aqueous Hydrofluoric Acid Mediated by Iodosylarenes
Further Information
Publication History
Received: 25 July 2013
Accepted after revision: 06 August 2013
Publication Date:
29 August 2013 (online)
Abstract
Direct fluorination of 1,3-dicarbonyl compounds including 1,3-diketones, 3-oxo esters, and 3-oxoamides was conducted using aqueous hydrofluoric acid with the aid of iodosylarenes, giving the corresponding 2-fluorinated products in good to high yields. Among the used iodosylarenes, o-iodosyltoluene was found to be the most effective, and the yield of 2-fluorinated products was improved.
Key words
fluorination - hypervalent iodine - 1,3-dicarbonyl compound - iodosylarene - hydrofluoric acidSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
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For recent reviews on hypervalent iodine compounds, see: