A new three-component strategy for the efficient synthesis of 2,3,5-trisubstituted thiophene derivatives through a [2+2+1] heterocyclization between 3-(2-aryl-2-oxoethylidene)-2-oxindoles and α-thiocyanato ketones under microwave irradiation is described. The bond-forming efficiency, accessibility, and generality of this synthesis make it highly valuable to assemble thiophene scaffolds.
Key words
heterocyclization - substituted thiophene - three-component reactions - α-thiocyanato ketone - 3-(2-aryl-2-oxoethylidene)-2-oxindole