Ammonium Chloride-Catalyzed Three-Component Reaction for the Synthesis of Fused 4H-Chromene Derivatives in Aqueous Medium

This work is dedicated to Professor Gautam Barua, former Director of the Indian Institute of Technology, Guwahati for his immense contribution­ in setting up and developing the Science Department of IIT Guwahati.

Abstract

An efficient one-pot process was developed to synthesize 4H-chromene derivatives using a three-component reaction involving salicylaldehydes, cyclic 1,3-diketones, and thiols in an aqueous medium at room temperature. This protocol was accomplished using the inexpensive and readily available catalyst NH₄Cl. The attractive features of this protocol are: use of inexpensive catalyst NH₄Cl, good yields, and mild and environmentally benign reaction conditions.

Key words

4H-chromenes - salicylaldehydes - cyclic 1,3-diketones - thiols - ammonium chloride - aqueous medium - multicomponent reactions (MCRs)

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