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Synlett 2014; 25(1): 58-63
DOI: 10.1055/s-0033-1340306
DOI: 10.1055/s-0033-1340306
new tools in synthesis
Time-Pulsed Vacuum and Time-Pulsed Alternating Pressure Chromatography
Further Information
Publication History
Received: 22 August 2013
Accepted after revision: 30 October 2013
Publication Date:
13 November 2013 (online)
Abstract
A comparison in separation efficiency between conventional chromatographic methods and newly devised time-pulsed methods (driven by either negative or positive pressure) is made. The methods are compared in terms of adsorbent amounts, solvent volumes, separation efficiency of a binary mixture, and the total time required for separation. It is found that alternating pressure or pulsed methods are superior on all counts compared to the conventional processes. This is supported by discussion of the principles as well as by the provision of detailed parameters for all experiments.
Key words
chromatography - solvent flow - time-pulsed vacuum - time-pulsed alternating pressure - new seperation methodsSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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