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Synlett 2014; 25(1): 58-63
DOI: 10.1055/s-0033-1340306
new tools in synthesis
© Georg Thieme Verlag Stuttgart · New York

Time-Pulsed Vacuum and Time-Pulsed Alternating Pressure Chromatography

Mary Ann A. Endoma-Arias
Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario, L2S 3A1, Canada   Fax: +1(905)9844841   eMail: thudlicky@brocku.ca
,
Ian D. Brindle
Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario, L2S 3A1, Canada   Fax: +1(905)9844841   eMail: thudlicky@brocku.ca
,
Tomas Hudlicky*
Chemistry Department and Centre for Biotechnology, Brock University, 500 Glenridge Avenue, St. Catharines, Ontario, L2S 3A1, Canada   Fax: +1(905)9844841   eMail: thudlicky@brocku.ca
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Publikationsverlauf

Received: 22. August 2013

Accepted after revision: 30. Oktober 2013

Publikationsdatum:
13. November 2013 (online)

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Abstract

A comparison in separation efficiency between conventional chromatographic methods and newly devised time-pulsed methods (driven by either negative or positive pressure) is made. The methods are compared in terms of adsorbent amounts, solvent volumes, separation efficiency of a binary mixture, and the total time required for separation. It is found that alternating pressure or pulsed methods are superior on all counts compared to the conventional processes. This is supported by discussion of the principles as well as by the provision of detailed parameters for all experiments.

Key words

chromatography - solvent flow - time-pulsed vacuum - time-pulsed alternating pressure - new seperation methods

Supporting Information

    for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
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