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Synlett 2014; 25(08): 1045-1049
DOI: 10.1055/s-0033-1340674
DOI: 10.1055/s-0033-1340674
synpacts
Post-Functionalization: A Useful Method for the Synthesis of Donor-Functionalized N-Heterocyclic Carbene–Transition-Metal Catalysts
Further Information
Publication History
Received: 21 November 2013
Accepted after revision: 04 January 2014
Publication Date:
11 February 2014 (online)
Abstract
Functionalized N-heterocyclic carbene ligands are particularly useful and widely applied ligands in transition-metal chemistry and catalysis. In this article we introduce an emerging synthetic method for functionalized N-heterocyclic carbene ligands developed from the reactivity study on cyclometalated N-heterocyclic carbene compounds, namely postfunctionalization. The status quo of this method for the preparation of novel donor-functionalized N-heterocyclic carbene complexes and their application in catalysis are discussed.
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Silyl-substituted NHC ligands could be synthesized by the conventional synthetic method. But the silyl groups on these NHC ligands only function as innocent substituents, rather than chelating donors. For examples, see:
Constructing phosphine- and pyridine-based chelating ligands from cyclometalated phosphine and pyridine compounds has precedents scattered in literature. For examples, see: