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Synlett 2014; 25(07): 939-944
DOI: 10.1055/s-0033-1340837
DOI: 10.1055/s-0033-1340837
letter
A Trifluoroacetic Acid Catalyzed Domino Reaction as an Approach to Amino Acid Derived 2,3-Dihydro-1H-1,5-benzodiazepines
Further Information
Publication History
Received: 14 December 2013
Accepted after revision: 28 January 2014
Publication Date:
11 March 2014 (online)
![](https://www.thieme-connect.de/media/synlett/201407/lookinside/thumbnails/10.1055-s-0033-1340837-1.jpg)
This paper is dedicated to Prof. M. Periasamy on his 60th birthday.
Abstract
Trifluoroacetic acid catalyzed condensation of aromatic amines with substituted benzaldehydes followed by intramolecular cyclization furnishes a highly effective synthesis of amino acid derived 2,3-dihydro-1H-1,5-benzodiazepines. The strategy provides an efficient access to a library of benzodiazepines that can be explored for potential pharmaceutical or biological activities.
Key words
amino acids - heterocycles - benzodiazepine - domino reaction - intramolecular cyclizationSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
-
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