The First Stereoselective Total Synthesis of the Immunosuppressive Decalin Derivative Monascusic Acid B^[1]

Abstract

The first stereoselective total synthesis of the immunosuppressive decalin derivative monascusic acid B has been accomplished from (R)-(+)-pulegone involving Horner–Wadsworth–Emmons and Julia–Kocienski olefination reactions and Lewis acid catalyzed intramolecular Diels–Alder cyclization.

Key words

monascusic acid B - total synthesis - (R)-(+)-pulegone - Horner–Wadsworth–Emmons olefination - Julia–Kocienski olefination - intramolecular Diels–Alder cyclization - immunosuppressive effect

• References and Notes

• 1 Part 74 in the series ‘Synthetic Studies on Natural Products’.
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