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Synthesis 2014; 46(07): 864-870
DOI: 10.1055/s-0033-1340868
DOI: 10.1055/s-0033-1340868
feature article
Catalytic Enantioselective Total Synthesis of (–)-Pyridovericin
Weitere Informationen
Publikationsverlauf
Received: 17. Dezember 2013
Accepted after revision: 06. Februar 2014
Publikationsdatum:
27. Februar 2014 (online)
Abstract
The first enantioselective catalytic total synthesis of (–)-pyridovericin is reported. The key steps involve a modified HWE reaction under aqueous conditions and an asymmetric iridium-catalyzed hydrogenation. This resulted in a highly modular and stereoselective approach that delivered the target natural product in high yield and stereoselectivity.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis. Included are 1H and 13C NMR spectra and HPLC traces.
- Supporting Information
-
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