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Synlett 2014; 25(07): 961-964
DOI: 10.1055/s-0033-1340920
DOI: 10.1055/s-0033-1340920
letter
Unexpected Beneficial Effect of ortho-Substituents on the (S)-Proline-Catalyzed Asymmetric Aldol Reaction of Acetone with Aromatic Aldehydes
Weitere Informationen
Publikationsverlauf
Received: 04. Februar 2014
Accepted: 16. Februar 2014
Publikationsdatum:
25. März 2014 (online)
![](https://www.thieme-connect.de/media/synlett/201407/lookinside/thumbnails/10.1055-s-0033-1340920-1.jpg)
Abstract
An intriguing effect of electronegative 2,6-substituents on the stereochemical outcome of (S)-proline-catalyzed aldol reactions between benzaldehyde derivatives and acetone is reported. Remarkably high enantioselectivities can be achieved with such substrates.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
-
References and Notes
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For recent reviews, see:
Some selected examples of designed catalysts: