Intensivmedizin up2date 2014; 10(02): 117-128
DOI: 10.1055/s-0034-1365160
Allgemeine Prinzipien der Intensivmedizin
© Georg Thieme Verlag KG Stuttgart · New York

Prävention der beatmungsassoziierten Pneumonie[*]

Karl Lewalter
,
Sebastian Lemmen
,
Simone Scheithauer
Weitere Informationen

Publikationsverlauf

Publikationsdatum:
20. März 2014 (online)

Kernaussagen
  • Die beatmungsassoziierte Pneumonie (VAP) ist die häufigste nosokomiale Infektion auf Intensivstationen und von großer medizinischer und ökonomischer Relevanz.

  • Als wesentlicher Pathomechanismus gilt die Mikroaspiration. Übersedierung, unnötige Beatmung und die Vernachlässigung krankenhaushygienischer Präventionsmaßnahmen sind die wesentlichen Ursachen für die VAP.

  • Zur Vermeidung der VAP stehen viele Interventionsmöglichkeiten mit unterschiedlicher Evidenz zur Verfügung.

  • Besonders bewährt hat sich die Einführung einiger ausgewählter, evidenzbasierter Maßnahmen als Bündel.

  • Bleibt trotz Ausschöpfung aller Basismaßnahmen die VAP-Rate hoch, kann man weitere Maßnahmen erwägen, wie z. B. subglottische Sekretabsaugung oder SOD bzw. SDD.

  • Den Erfolg infektionspräventiver Maßnahmen sollte man durch die Teilnahme an Surveillanceprogrammen überprüfen (z. B. KISS).

* Die Erstpublikation dieses Beitrags erschien in Krankenh hyg up2date 2012; 7 (4): 275–289. DOI: 10.1055/s-0032-1325954


Die Literatur zu diesem Beitrag finden Sie unter http://dx.doi.org/10.1055/s-0034-1365160.

 
  • Literatur

  • 1 Robert-Koch-Institut. Deutsche Daten im Rahmen der ersten europäischen Prävalenzerhebung zum Vorkommen nosokomialer Infektionen und zur Antibiotikaanwendung. Epid Bull 2012; 26: 239-240
  • 2 Safdar N, Crnich CJ, Maki D. The pathogenesis of ventilator associated pneumonia: its relevance to developing effective strategies for prevention. Resp Care 2005; 50: 725-741
  • 3 Pawar M, Mehta Y, Khurana P et al. Ventilator-associated pneumonia: incidence, risk factors, outcome and microbiology. J Cardiothorac Vasc Anesth 2003; 17: 22-28
  • 4 Cook DJ, Walter SD, Cook RJ et al. Incidence of and risk factors for ventilator-associated pneumonia in critically ill adults. Ann Intern Med 1998; 129: 433-440
  • 5 Klompas M. Does this patient have ventilator-associated pneumonia?. J Am Med Assoc 2007; 297: 1583-1593
  • 6 Dahlhoff K, Abele-Horn M, Andreas S et al. Epidemiologie, Diagnostik und Therapie erwachsener Patienten mit nosokomialer Pneumonie. Pneumologie 2012; 66: 707-765
  • 7 Gastmeier P, Sohr D, Geffers C et al. Early- and late-onset pneumonia: is this still a useful classification?. Antimicrob Agents Chemother 2009; 53: 2714-2718
  • 8 Tablan OC, Anderson LJ, Besser R et al. Guidelines for preventing health-care-associated pneumonia, 2003: recommendations of CDC and the Healtcare Infection Control Practices Advisory Committee. MMWR Recomm 2004; 53: 1-36
  • 9 Kollef MH, Hamilton CW, Ernst FR. Economic impact of ventilator-associated pneumonia in a large matched cohort. Infect Control Hosp Epidemiol 2012; 33: 250-256
  • 10 Moller AH, Hansen L, Jensen MS et al. A cost-effectiveness analysis of reducing ventilator-associated pneumonia at a Danish ICU with ventilator bundle. J Med Econ 2012; 15: 285-292
  • 11 Melsen WG, Rovers MM, Groenwold RHH et al. Attributable mortality of ventilator-associated pneumonia: a meta-analysis of individual patient data from randomised prevention studies. Lancet Infect Dis 2013; 13: 665-671
  • 12 Berwick DM, Calkins DR, McCannon CJ et al. The 100.000 Lives Campaign. Setting a goal and a deadline for improving health care quality. J Am Med Assoc 2006; 295: 324-327
  • 13 Girard TD, Kress JP, Fuchs BD et al. Efficacy and safety of a paired sedation and ventilator-weaning protocol for mechanically ventilated patients in intensive care: a randomized controlled trial. Lancet 2008; 371: 126-134
  • 14 Zuschneid I, Schwab F, Geffers C et al. Trends in ventilator associated pneumonia rates within the German Nosocomial Infection Surveillance System (KISS). Infect Control Hosp Epidemiol 2007; 28: 314-318
  • 15 Umscheid CA, Mitchell MD, Doshi JA. Estimating the proportion of healthcare-associated infections that are reasonably preventable and the related mortality and costs. Infect Control Hosp Epidemiol 2011; 32: 101-114
  • 16 Salahuddin N, Zafar A, Sukhyani L et al. Reducing ventilator associated pneumonia rates through a staff education programme. J Hosp Inf 2004; 57: 223-227
  • 17 Ferrer R, Artigas A, Levy MM et al. Improvement in process of care and outcome after a multicenter severe sepsis educational program in spain. J Am Med Assoc 2008; 299: 2294-2303
  • 18 World Health Organization. WHO Guidelines for Hand Hygiene in Health Care. Geneva: WHO; 2009
  • 19 Koff MD, Corwin HL, Beach ML et al. Reduction in ventilator associated pneumonia in a mixed intensive care unit after initiation of a novel hand hygiene program. J Crit Care 2011; 26: 489-495
  • 20 Rewa O, Muscedere J. Ventilator-associated pneumonia: update on etiology, prevention and management. Curr Infect Dis Rep 2011; 13: 287-295
  • 21 Brochard L. Mechanical ventilation: invasive versus noninvasive. Eur Respir J 2003; 22: 31-37
  • 22 Craven DE, Lichtenberg DA, Goularte TA et al. Contaminated medication nebulizers in mechanical ventilator circuits. Am J Med 1984; 77: 834-838
  • 23 Branson RD. The ventilator circuit and ventilator-associated pneumonia. Resp Care 2005; 50: 774-787
  • 24 Artinian V, Krayem H, DiGiovine B. Effects of early enteral feeding on the outcome of critically ill mechanically ventilated medical patients. Chest 2006; 129: 960-967
  • 25 Gramlich L, Kichian K, Pinilla J. Does enteral nutrition compared to parenteral nutrition result in better outcomes in critically ill adult patients? A systematic review of the literature. Nutrition 2004; 20: 843-848
  • 26 Marik PE, Zaloga GP. Gastric versus postpyloric feeding: a systematic review. Crit Care 2003; 7: R46-51
  • 27 Reignier J, Mercier E, Le Gouge A. Effect of not monitoring residual gastric volume on risk of ventilator-associated pneumonia in adults receiving mechanical ventilation and early enteral feeding: a randomized controlled trial. JAMA 2013; 309: 249-256
  • 28 Alhazzani W, Almasoud A, Jaeschke R. Small bowel feeding and risk of pneumonia in adult critically ill patients: a systematic review and meta-analysis of randomized trials. Crit Care 2013; 17: R127
  • 29 Kommission für Krankenhaushygiene und Infektionsprävention am Robert-Koch-Institut. Prävention der nosokomialen beatmungsassoziierten Pneumonie. Bundesgesundheitsbl 2013; 56: 1578-1590
  • 30 Alhazzani W, Alenezi F, Jaeschke RZ. Proton pump inhibitors versus histamine 2 receptor antagonists for stress ulcer prophylaxis in critically ill patients: a systematic review and meta-analysis. Crit Care Med 2013; 41: 693-705
  • 31 Huang J, Cao Y, Liao C et al. Effect of histamine-2-receptor antagonists versus sucralfate on stress ulcer prophylaxis in mechanically ventilated patients: a meta-analysis of 10 randomized controlled trials. Crit Care 2010; 14: R194
  • 32 Siempos II, Vardakas KZ, Kopterides P et al. Impact of passive humidification on clinical outcomes of mechanically ventilated patients: a meta-analysis of randomized controlled trials. Crit Care Med 2007; 35: 2843-2851
  • 33 Kelly M, Gillies D, Todd DA et al. Heated humidifiers versus heat and moisture exchangers for ventilated adults and children. Cochrane Database Syst Rev 2010; CD004711
  • 34 Drakulovic M, Torres A, Bauer TT et al. Supine body position as a risk factor for nosocomial pneumonia in mechanically ventilated patients: a randomized trial. Lancet 1999; 354: 1851-1858
  • 35 Van Nieuwenhoven CA, Vandenbroucke-Grauls C, van Thiel FH et al. Feasibility and effects of the semirecumbent position to prevent ventilator-associated pneumonia: a randomized study. Crit Care Med 2006; 34: 396-402
  • 36 Han J, Liu Y. Effect of ventilator circuit changes on ventilator associated pneumonia: a systematic review and meta-analysis. Resp Care 2010; 55: 467-474
  • 37 Lorente L, Lecuona M, Martin M et al. Ventilator-associated pneumonia using a closed versus an open tracheal suction system. Crit Care Med 2005; 33: 115-119
  • 38 Morrow LE, Kollef MH, Casale TB. Probiotic prophylaxis of ventilator-associated pneumonia. Am J Respir Crit Care 2010; 182: 1058-1064
  • 39 Gu WJ, Wei CY, Yin RX. Lack of efficacy of probiotics in preventing ventilator-associated pneumonia: a systematic review and meta-analysis of randomized controlled trials. Chest 2012; DOI DOI: 10.1378/chest.12–0679.
  • 40 Terragni PP, Antonelli M, Fumagalli R et al. Early vs late tracheotomy for prevention of pneumonia in mechanically ventilated adult ICU patients. J Am Med Assoc 2010; 303: 1483-1489
  • 41 Labeau SO, Van de Vyver K, Brusselaers N et al. Prevention of ventilator-associated pneumonia with oral antiseptics: a systematic review and meta-analysis. Lancet Infect Dis 2011; 11: 845-854
  • 42 Chan EY, Ruest A, O’Meade M et al. Oral decontamination for prevention of pneumonia in mechanically ventilated adults: a systematic review and meta-analysis. Br Med J 2007; 334: 889-1000
  • 43 Lorente L, Lecunoa M, Jimenez A et al. Ventilator-associated pneumonia with or without toothbrushing: a randomized controlled trial. Eur J Clin Microbiol Infect Dis 2012; 31: 2621-2629
  • 44 Schultz MJ, Haas LE. Antibiotics or probiotics as preventive measures against ventilator-associated pneumonia: a literature review. Crit Care 2011; 15: R18
  • 45 de Smet AMGA, Kluytmans JAJW, Cooper BS et al. Decontamination of the digestive tract and oropharynx in ICU patients. N Engl J Med 2009; 360: 20-31
  • 46 de Smet AMGA, Bonten MJM, Kluytmans JAJW. For whom should we use selective decontamination of the digestive tract?. Curr Opin Infect Dis 2012; 25: 211-217
  • 47 Oosdijk EAN, de Smet AMGA, Blok HEM et al. Ecological effects of selective decontamination on resistant gram-negative bacterial colonization. Am J Respir Crit Care Med 2010; 181: 452-457
  • 48 Muscedere J, Rewa O, Mckechnie K et al. Subglottic secretion drainage for the prevention of ventilator-associated pneumonia: a systematic review and meta-analysis. Crit Care Med 2011; 38: 1985-1991
  • 49 Valencia M, Ferrer M, Farre R et al. Automatic control of tracheal tube cuff pressure in ventilated patients in semirecumbent position: a randomized trial. Crit Care Med 2007; 35: 1543-1549
  • 50 Nseir S, Zerimech F, Fournier C et al. Continuous control of tracheal cuff pressure and microaspiration of gastric contents in critically ill patients. Am J Respir Crit Care Med 2011; 184: 1041-1047
  • 51 Kollef MH, Afessa B, Anzueto A et al. Silver-coated endotracheal tubes and incidence of ventilator-associated pneumonia. J Am Med Assoc 2008; 300: 805-813
  • 52 Lorente L, Blot S, Rello J. New issues and controversies in the prevention of ventilator-associated pneumonia. Am J Respir Crit Care Med 2010; 182: 870-876
  • 53 Lorente L, Lecunoa M, Jimenez A et al. Influence of an endotracheal tube with polyurethane cuff and subglottic secretion drainage on pneumonia. Am J Crit Care Med 2007; 176: 1079-1083
  • 54 Miller MA, Arndt JL, Konkle MA et al. A polyurethane cuffed endotracheal tube is associated with decreased rates of ventilator-associated pneumonia. J Crit Care 2011; 26: 280-286
  • 55 Manzano F, Fernández-Mondéjar E, Colmenero M et al. Positive-end expiratory pressure reduces the incidence of ventilator-associated pneumonia in nonhypoxemic patients. Crit Care Med 2008; 36: 2225-2231
  • 56 Schulze-Röbbecke R. Bündel zur Prävention nosokomialer Infektionen. Krankenh hyg up2date 2011; 6: 9-23
  • 57 Al-Tawfiq JA, Abed MS. Decreasing ventilator-associated pneumonia in adult intensive care units using the Institute for Healthcare Improvement bundle. Am J Infect Control 2010; 38: 552-556
  • 58 Morris AC, Hay AW, Swann DG et al. Reducing ventilator-associated pneumonia in intensive care: impact of implementing a care bundle. Crit Care Med 2011; 39: 2218-2224
  • 59 Hawe CS, Ellis KS, Cairns CJS et al. Reduction of ventilator associated pneumonia: active versus passive guideline implementation. Intensive Care Med 2009; 35: 1180-1186