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Klin Monbl Augenheilkd 2014; 231(4): 411-413
DOI: 10.1055/s-0034-1368287
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Georg Thieme Verlag KG Stuttgart · New York

RPE Adenocarcinoma Arising from a Congenital Hypertrophy of the RPE (CHRPE) Treated with Proton Therapy

RPE-Adenokarzinom an einer kongenitalen Hypertrophie des RPE behandelt mit Protonentherapie
A. P. Moulin
Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland
,
L. Zografos
Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland
,
A. Schalenbourg
Department of Ophthalmology, University of Lausanne, Jules-Gonin Eye Hospital, FAA, Lausanne, Switzerland
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Publication Date:
25 April 2014 (online)

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Introduction

Congenital hypertrophy of the retinal pigment epithelium (CHRPE) can present as a solitary or multiple flat pigmented fundus lesions which may slightly enlarge over years [1], [2]. In a series of 330 solitary CHRPE, a flat, horizontal enlargement could be noticed in 83 %, after more than three years. In this study [2], the median growth rate was estimated at 2 µm/mm base lesion/month. In some rare cases, a nodular, vertical growth in a CHRPE has been described [3], [4], [5], [6]. Only three of these underwent a histopathological analysis diagnosing an RPE adenocarcinoma arising from CHRPE [4], [5], [6].

We report the clinico-pathological findings of an RPE adenocarcinoma arising from CHRPE that – to the best of our knowledge – was the first to be, successfully, treated with proton beam radiotherapy.

 

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