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Drug Res (Stuttg) 2015; 65(05): 259-265
DOI: 10.1055/s-0034-1377003
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Two New Flavonoids and Biological Activity of Astragalus abyssinicus (Hochst.) Steud. ex A. Rich. Aerial Parts

R. A. El Dib
1   Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh Saudi Arabia
2   Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt
,
H. S. M. Soliman
2   Department of Pharmacognosy, Faculty of Pharmacy, Helwan University, Cairo, Egypt
3   Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Kingdom of Saudi Arabia
,
M. H. Hussein
4   Department of Pharmacognosy, College of Pharmacy, Al-Azhar University, Cairo, Egypt
,
H. G. Attia
5   Department of Pharmacognosy, College of Pharmacy, Najran Univeristy, Najran, Kingdom of Saudi Arabia
› Author Affiliations
Further Information

Publication History

received 28 February 2014

accepted 05 May 2014

Publication Date:
18 June 2014 (online)

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Abstract

2 new flavonoid glycosides, kaempferol 3-O-(4″,6″-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (1) and quercetin 3-O-(4″,6″-di-O-α-L-rhamnopyranosyl)-β-D-glucopyranoside (2), were isolated from the n-butanol soluble fraction of the methanol extract (BF) of Astragalus abyssinicus aerial parts, together with 3 known compounds, rutin (3), kaempferol 3-O-β-D-rutinoside (4) and 5,7,4′-trihydroxy-3′-methoxyisoflavone (5). The structures of the isolated compounds were characterized on the basis of UV, NMR and negative ESI-MS analyses. The BF fraction showed in vitro weak antibacterial activity against Staphylococcus aureus, while 2 and 3 exhibited in vitro antioxidant activity higher than ascorbic acid using DPPH free radical scavenging activity method.

Key words

Astragalus abyssinicus - Fabaceae - Isolation - Flavonoids - Antibacterial activity - Antioxidant activity
 

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