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Synlett 2014; 25(12): 1713-1716
DOI: 10.1055/s-0034-1378276
DOI: 10.1055/s-0034-1378276
letter
Decarboxylative Knoevenagel-Type Reactions on Tetronamides: Synthesis of 5-Ylidene-4-Amino-2(5H)-Furanones
Further Information
Publication History
Received: 11 April 2014
Accepted after revision: 11 May 2014
Publication Date:
06 June 2014 (online)
Abstract
A detailed account regarding the synthesis of 5-ylidene-2(5H)-furanones is given. The key step is a decarboxylative Knoevenagel-type reaction of tetronamides with various α-functionalized aldehydes. The synthesis of protected basidalin is presented.
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For cyclizations with NBS, see:
For recent publications concerning the Doebner reaction, see: