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Synthesis 2014; 46(19): 2651-2655
DOI: 10.1055/s-0034-1378383
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© Georg Thieme Verlag Stuttgart · New York

Synthesis of Carbalexin B, Clausine A, Clauszoline M, and 2,8-Dihydroxy-3-methylcarbazole

Konstanze K. Julich-Gruner
Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany   Fax: +49(351)46337030   Email: hans-joachim.knoelker@tu-dresden.de
,
Arndt W. Schmidt
Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany   Fax: +49(351)46337030   Email: hans-joachim.knoelker@tu-dresden.de
,
Hans-Joachim Knölker*
Department of Chemistry, Technische Universität Dresden, Bergstraße 66, 01069 Dresden, Germany   Fax: +49(351)46337030   Email: hans-joachim.knoelker@tu-dresden.de
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Publication History

Received: 10 June 2014

Accepted: 17 June 2014

Publication Date:
08 July 2014 (online)

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Abstract

Using a palladium(II)-catalyzed oxidative cyclization of an N,N-diarylamine, we have achieved the total synthesis of the 2,8-dioxygenated carbazole alkaloids carbalexin B, clausine A, clauszoline M, and 2,8-dihydroxy-3-methylcarbazole.

Key words

alkaloids - catalysis - cyclization - natural products - palladium

Supporting Information

    for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000084.
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