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DOI: 10.1055/s-0034-1378706
Enamide Derivatives: Versatile Building Blocks for Total Synthesis
Publication History
Received: 30 January 2015
Accepted after revision: 16 March 2015
Publication Date:
27 May 2015 (online)
Abstract
Enamides and enecarbamates are versatile building blocks in organic synthesis. This review describes the development of enamide chemistry and the utility of the resulting products in the synthesis of a variety of important, biologically active molecules.
1 Introduction
2 Asymmetric Hydrogenation of Enamides
3 Monofunctionalization of Enamide Derivatives
3.1 Palladium-Catalyzed α-Functionalization of Enamide Derivatives
3.2 Ruthenium-Catalyzed β-Functionalization of Enamide Derivatives
4 Ionic Vicinal Difunctionalization of Enamide Derivatives
4.1 Tandem Difunctionalization of Enamide Derivatives
4.2 Cycloadditions
4.2.1 [4+2] Cycloadditions
4.2.2 [2+2] Cycloadditions
4.2.3 Cyclopropanation of Enamides
4.3 Other Pericyclic Reactions
4.3.1 Electrocyclization Reactions
4.3.2 Overman Rearrangement
4.4 Platinum-Catalyzed Vicinal Difunctionalization of Enamide Derivatives
5 Radical Vicinal Difunctionalization of Enamide Derivatives
6 Oxidative Vicinal Difunctionalization of Enamide Derivatives
7 N-Arylation of Enecarbamates
8 Conclusion
9 Ligand Glossary
-
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Also see:
For a review on electrophilic and nucleophilic substitution and addition reactions of enamines, see:
For a review covering asymmetric organocatalysis, see:
For selected reviews on enamine catalysis, see:
Selected examples, see:
For reviews see:
For reviews on RCM in total synthesis see:
For a review see:
For reviews, see: