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DOI: 10.1055/s-0034-1378712
Organocatalytic Strategies for the Synthesis of Axially Chiral Compounds
Publication History
Received: 29 March 2015
Accepted after revision: 28 April 2015
Publication Date:
24 June 2015 (online)
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Abstract
Atropisomers are compounds in which chirality arises from hindered rotation along the carbon–carbon or carbon–heteroatom single bond. Recently, organocatalysis appeared to be a rapid, valuable, and efficient strategy for their preparation in an enantioselective manner. In this report a general overview of the most important organocatalyzed atroposelective transformations will be given pointing out in particular the specific role played by the catalyst.
1 Dynamic Kinetic Resolution
2 Desymmetrization of Biaryls
3 Direct Synthesis of Biaryls
4 Asymmetric Friedel–Crafts Amination of Naphthols
5 N-Alkylation via Phase-Transfer Catalysis
6 Desymmetrization of N-Arylmaleimides
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