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Synlett 2015; 26(15): 2135-2138
DOI: 10.1055/s-0034-1378803
DOI: 10.1055/s-0034-1378803
letter
Synthesis of Allenyl Esters by Horner–Wadsworth–Emmons Reactions of Ketenes Mediated by Isopropylmagnesium Bromide
Further Information
Publication History
Received: 03 June 2015
Accepted after revision: 17 June 2015
Publication Date:
10 August 2015 (online)
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Abstract
The synthesis of conjugated allenyl esters (tri-substituted allenes) was achieved by magnesium(II)-mediated Horner–Wadsworth–Emmons reaction of methyl bis(2,2,2-trifluoroethyl)phosphonoacetate with disubstituted ketenes. In addition, a novel access to α-fluorinated allenyl carboxamides (tetrasubstituted allenes) is presented.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1378803.
- Supporting Information
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For examples of HWE reactions, see:
For examples of Wittig reactions, see: