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Synlett 2015; 26(03): 340-344
DOI: 10.1055/s-0034-1379247
DOI: 10.1055/s-0034-1379247
cluster
Cobalt-Catalyzed Directed Alkylation of Olefinic C–H Bond with Primary and Secondary Alkyl Chlorides
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Publication History
Received: 28 August 2014
Accepted: 15 September 2014
Publication Date:
15 October 2014 (online)


Abstract
A cobalt–N-heterocyclic carbene catalytic system promotes pyridine-directed olefinic C–H alkylation reactions using a variety of primary and secondary alkyl chlorides under mild conditions. Radical clock experiments suggest that the reaction involves single-electron transfer from the cobalt intermediate to the alkyl chloride.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/products/ejournals/journal/ 10.1055/s-00000083.
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