Synlett 2015; 26(03): 345-349
DOI: 10.1055/s-0034-1379319
cluster
© Georg Thieme Verlag Stuttgart · New York

Copper-Catalyzed Aerobic C–H Trifluoromethylation of Phenanthrolines

Cheng-Liang Zhu
,
Yong-Qiang Zhang
,
Yong-An Yuan
,
Hao Xu*
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Publication History

Received: 01 September 2014

Accepted after revision: 22 September 2014

Publication Date:
21 October 2014 (online)


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Abstract

Direct C–H trifluoromethylation of heterocycles is a valuable transformation. In particular, nonprecious metal-catalyzed C–H trifluoromethylation processes, which do not proceed through CF3 radical species, have been less developed. In this cluster report, a new copper-catalyzed aerobic C–H trifluoromethylation of phenanthrolines is described. This transformation affords trifluoromethylated phenanthrolines that have not been synthesized and preliminary mechanistic studies suggest that the CF3 group transfer may occur through cooperative activation.

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