3,5-Disubstituted 2-Aminopyridines via Nickel-Catalyzed Cycloaddition of Terminal Alkynes and Cyanamides

Yao Zhong; Nathan A. Spahn; Ryan M. Stolley; Minh H. Nguyen; Janis Louie

doi:10.1055/s-0034-1379500

Synlett, Table of Contents

Synlett 2015; 26(03): 307-312
DOI: 10.1055/s-0034-1379500

cluster

3,5-Disubstituted 2-Aminopyridines via Nickel-Catalyzed Cycloaddition of Terminal Alkynes and Cyanamides

Yao Zhong

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA Fax: +1(801)5818433 Email: louie@chem.utah.edu

,

Nathan A. Spahn

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA Fax: +1(801)5818433 Email: louie@chem.utah.edu

,

Ryan M. Stolley

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA Fax: +1(801)5818433 Email: louie@chem.utah.edu

,

Minh H. Nguyen

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA Fax: +1(801)5818433 Email: louie@chem.utah.edu

,

Janis Louie*

Department of Chemistry, University of Utah, 315 South 1400 East, Salt Lake City, UT, 84112, USA Fax: +1(801)5818433 Email: louie@chem.utah.edu

› Author Affiliations

Abstract

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Abstract

The regioselectivity of the Ni/SIPr-catalyzed cycloaddition of terminal alkynes and cyanamides was explored. In general, 3,5-disubstituted 2-aminopyridines were formed as the major product.

Key words

nickel - catalyst - cycloaddition - 2-aminopyridines - regioselectivity

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References

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