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Synlett 2015; 26(02): 271-272
DOI: 10.1055/s-0034-1379776
DOI: 10.1055/s-0034-1379776
spotlight
β-Trifluoromethyl-α,β-unsaturated Ketones
Weitere Informationen
Publikationsverlauf
Publikationsdatum:
22. Dezember 2014 (online)
![](https://www.thieme-connect.de/media/synlett/201502/lookinside/thumbnails/10.1055-s-0034-1379776-1.jpg)
Introduction
β-Trifluoromethyl enones are important synthetic precursors of molecules containing chiral centers with a trifluoromethyl substituent, a structural motif which is present in biologically active compounds, chiral reagents and in materials for optoelectronic devices.[1] The presence of the strong electron-withdrawing β-trifluoromethyl group increases the electrophilicity of the double bond expediting the conjugate nucleophilic additions.
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