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Synthesis 2015; 47(11): 1560-1566
DOI: 10.1055/s-0034-1379899
DOI: 10.1055/s-0034-1379899
paper
Palladium/N-Heterocyclic Carbene Catalyzed Mono- and Double-Cyanation of Aryl Halides Using Potassium Ferrocyanide Trihydrate under Aerobic Conditions
Weitere Informationen
Publikationsverlauf
Received: 23. Dezember 2014
Accepted after revision: 02. Februar 2015
Publikationsdatum:
30. März 2015 (online)
Abstract
A practical palladium/N-heterocyclic carbene catalyzed procedure for the mono- and double-cyanation of aryl halides is described using inexpensive, easy-to-handle and nontoxic potassium ferrocyanide trihydrate {K4[Fe(CN)6]·3H2O} as the cyanating agent. The reaction does not require an anhydrous solvent, or the exclusion of air or moisture. A variety of electron-rich and electron-deficient aryl halides are efficiently converted into their corresponding nitriles and dicarbonitriles.
Key words
cyanation - N-heterocyclic carbene - palladium catalysis - potassium ferrocyanide - aerobic conditionsSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379899.
- Supporting Information
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