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Synthesis 2015; 47(15): 2294-2298
DOI: 10.1055/s-0034-1379916
DOI: 10.1055/s-0034-1379916
paper
A Rapid One-Pot Ugi Reaction Based Route to Novel Imidazole-Fused Benzodiazepinones
Weitere Informationen
Publikationsverlauf
Received: 30. Januar 2015
Accepted after revision: 27. März 2015
Publikationsdatum:
05. Mai 2015 (online)
Abstract
A short and efficient synthetic approach has been developed for the synthesis of a variety of imidazole-fused benzodiazepinones. It is based on a Ugi multicomponent reaction strategy and uses various isocyanides to generate the key intermediates for a Mumm rearrangement process. The method is suitable for rapid syntheses of fused azaheterocycles of pharmacological interest.
Key words
multicomponent reactions - heterocycles - fused-ring systems - isocyanides - imidazoles - rearrangementsSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1379916.
- Supporting Information
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