Synthesis of Pyrido[2,3-c]coumarin Derivatives by an Intramolecular Povarov Reaction

Abstract

Fused pyrido[2,3-c]coumarin derivatives were prepared by an intramolecular Povarov reaction of 2-(propagyloxy)benzaldehydes with 3-aminocoumarins in the presence of 10 mol% of triflic acid as a catalyst in refluxing acetonitrile. Among the advantages of this protocol are shorter reaction times, good yields, and the absence of the need for aqueous workup and chromatographic separation.

Key words

heterocycles - pyridines - coumarins - fused-ring systems - Diels–Alder reactions - cyclizations - catalysis

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