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Synthesis 2015; 47(11): 1623-1632
DOI: 10.1055/s-0034-1380322
DOI: 10.1055/s-0034-1380322
paper
The Reaction of 2-(Acylamino)benzonitriles with Primary Aromatic Amines: A Convenient Synthesis of 2-Substituted 4-(Arylamino)quinazolines
Further Information
Publication History
Received: 06 January 2015
Accepted after revision: 12 February 2015
Publication Date:
17 March 2015 (online)
Abstract
2-Substituted 4-(arylamino)quinazolines were prepared from 2-(acylamino)benzonitriles and primary arylamines by refluxing in either ethanol using trifluoroacetic acid as a catalyst or acetic acid. The 2-aminobenzonitrile was acylated by reaction with anhydrides, isocyanates, or ethyl chloroformate at room temperature.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380322.
- Supporting Information
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