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Synlett 2015; 26(10): 1283-1288
DOI: 10.1055/s-0034-1380412
DOI: 10.1055/s-0034-1380412
synpacts
Recent Advances in the Synthesis of 2-Substituted Oxetanes
Further Information
Publication History
Received: 22 January 2015
Accepted after revision: 12 February 2015
Publication Date:
16 March 2015 (online)
Abstract
Recent interest in oxetanes in medicinal chemistry and as synthetic intermediates has led to the development of a number of methods for the synthesis of more functionalized and highly substituted oxetane derivatives. Here we review cyclization approaches for the preparation of 2-substituted oxetanes. Methods involving C–O bond formation, as well as recently developed C–C bond forming cyclization strategies are highlighted.
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References
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For selected recent examples, see:
For other studies on deprotonation of oxetanes and trapping with electrophiles, see: