Toward a Green Atom Economy: Development of a Sustainable Multicomponent Reaction

Silvia Garbarino; Stefano Protti; Andrea Basso

doi:10.1055/s-0034-1380719

Synthesis, Inhaltsverzeichnis

Synthesis 2015; 47(16): 2385-2390
DOI: 10.1055/s-0034-1380719

special topic

Toward a Green Atom Economy: Development of a Sustainable Multicomponent Reaction

Silvia Garbarino

^aBioorganic Chemistry Group, Department of Chemistry and Industrial Chemistry, University of Genova, Via Dodecaneso 31, 16146 Genova, Italy eMail: andrea.basso@unige.it

,

Stefano Protti*

^bPhotoGreen Lab, Department of Chemistry University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy eMail: prottistefano@gmail.com

,

Andrea Basso*

^aBioorganic Chemistry Group, Department of Chemistry and Industrial Chemistry, University of Genova, Via Dodecaneso 31, 16146 Genova, Italy eMail: andrea.basso@unige.it

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Abstract

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Abstract

The recently discovered photoinduced three-component reaction of diazo ketones, carboxylic acids, and isocyanides can be efficiently performed under continuous-flow conditions with consequential advantages in terms of selectivity and productivity. The investigation of the flow process and the determination of its sustainability are discussed in detail. This multicomponent reaction affords stereodefined captodative olefins, useful as synthons in organic chemistry.

Key words

multicomponent reactions - photochemistry - flow chemistry - green chemistry - diazo compounds - isocyanides

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Referenzen

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