Synthesis of an Intermediate of Nafoxidine via Nickel-Catalyzed Ketone Arylation

Abstract

A nickel-catalyzed methodology for the α-arylation of ketones has been applied to the synthesis of an industrially relevant intermediate. The optimization of the reaction shows the important influence of subtle changes in reaction conditions, and leads to an improved procedure employing only a small excess of the substrate and a relatively low catalyst loading.

Key words

nickel - ketones - arylation - cross coupling - medicinal chemistry

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