Domino Aryne Precursor: A Step beyond the Boundary of Traditional Aryne Chemistry

Abstract

In an aim to expand the scope of aryne chemistry with new synthons, a domino aryne precursor bearing an additional ortho-OTf group on Kobayashi reagent is proposed and synthesized. 2,4-Disubstituted benzothiazole could be achieved from benzothioamide derivatives and this reagent with a sequential incorporation of C–S, C–N, and C–C bonds on the consecutive positions of the aryne precursor.

Key words

aryne - domino aryne chemistry - benzyne - Kobayashi reagent - benzothiazole

• References

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