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Synlett 2015; 26(18): 2505-2511
DOI: 10.1055/s-0034-1381051
DOI: 10.1055/s-0034-1381051
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Syntheses of Nitrogen-Containing Heterocycles via Palladium-Catalyzed Intramolecular Dehydrogenative C–H Amination
Further Information
Publication History
Received: 27 May 2015
Accepted after revision: 16 June 2015
Publication Date:
04 September 2015 (online)
Abstract
This article traces the development of catalytic, intramolecular dehydrogenative C–H amination (IDCA) reactions. Over the last 10 years, effective syntheses of carbazoles, indolines and oxindoles via palladium-catalyzed sp2 intramolecular dehydrogenative C–H amination reactions have been realized. While the corresponding amination reactions of sp3 C–H bonds are more challenging, syntheses of pyrrolidines, azetidines, β-lactams and even aziridines via this manifold have been reported.
1 Introduction
2 Intramolecular Aminations of C(sp2)–H Bonds
3 Intramolecular Aminations of C(sp3)–H Bonds
4 Conclusion
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