Syntheses of Nitrogen-Containing Heterocycles via Palladium-Catalyzed Intramolecular Dehydrogenative C–H Amination

Abstract

This article traces the development of catalytic, intramolecular dehydrogenative C–H amination (IDCA) reactions. Over the last 10 years, effective syntheses of carbazoles, indolines and oxindoles via palladium-catalyzed sp² intramolecular dehydrogenative C–H amination reactions have been realized. While the corresponding amination reactions of sp³ C–H bonds are more challenging, syntheses of pyrrolidines, azetidines, β-lactams and even aziridines via this manifold have been reported.

1 Introduction

2 Intramolecular Aminations of C(sp²)–H Bonds

3 Intramolecular Aminations of C(sp³)–H Bonds

4 Conclusion

Key words

palladium - nitrogen - heterocycles - metallacycles - cyclization

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