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Int J Sports Med 2015; 36(09): 761-768
DOI: 10.1055/s-0035-1547219
Genetics & Molecular Biology
© Georg Thieme Verlag KG Stuttgart · New York

Different Resistance-Training Regimens Evoked a Similar Increase in Myostatin Inhibitors Expression

A. R. Santos
1   School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil
2   School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
,
L. Lamas
2   School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
,
C. Ugrinowitsch
2   School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
,
V. Tricoli
2   School of Physical Education and Sport, University of São Paulo, São Paulo, Brazil
,
E. H. Miyabara
3   Department of Anatomy, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
,
A. G. Soares
4   Department of Pharmacology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil
,
M. S. Aoki
1   School of Arts, Sciences and Humanities, University of São Paulo, São Paulo, Brazil
› Author Affiliations
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Publication History



accepted after revision 29 January 2015

Publication Date:
30 March 2015 (online)

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Abstract

The aim of the present study was to investigate the effect of different resistance-training regimens (S or P) on the expression of genes related to the MSTN signaling pathway in physically-active men. 29 male subjects with at least 2 years of experience in strength training were assigned to either a strength-training group (S; n=11) or a power-training group (P; n=11). The control group (C; n=7) was composed of healthy physically-active males. The S and the P groups performed high- and low-intensity squats, respectively, 3 times per week, for 8 weeks. Muscle biopsies from the vastus lateralis muscle were collected before and after the training period. No change was observed in MSTN, ACTIIB, GASP-1 and FOXO-3 A gene expression after the training period. A similar increase in the gene expression of the inhibitory proteins of the MSTN signaling pathway, FLST (S: 4.2 fold induction and P: 3.7 fold induction, p<0.01) and FL-3 (S: 5.6 fold induction and P: 5.6 fold induction, p<0.01), was detected after the training period. SMAD-7 gene expression was similarly augmented after both training protocols (S: 2.5 fold induction; P: 2.8 fold induction; p<0.05). In conclusion, the resistance-training regimens (S and P) activated the expression of inhibitors of the MSTN signaling pathway in a similar manner.

Key words

strength training - power training - gene expression - real time PCR
 

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