RSS-Feed abonnieren

DOI: 10.1055/s-0035-1557748
Local and Systemic Therapies for Breast Cancer Patients: Reducing Short-term Symptoms with the Methods of Integrative Medicine
Lokale und systemische Therapien der Patientin mit Mammakarzinom: kurzfristige Symptome lindern mit Methoden der Integrativen MedizinPublikationsverlauf
received 20. Februar 2015
revised 21. Juni 2015
accepted 21. Juni 2015
Publikationsdatum:
30. Juli 2015 (online)

Abstract
With improved prognosis due to advances in the diagnosis and therapy of breast cancer, physicians and therapists now focus on aspects such as quality of life and the management of side effects from breast cancer treatment. Therapy- and disease-related side effects often reduce the patientʼs quality of life and can place a further burden on patients, with non-compliance or discontinuation of therapy a potential consequence. Study data have shown that therapy- and disease-related side effects can be reduced using the methods of integrative medicine. Reported benefits include improving patientsʼ wellbeing and quality of life, reducing stress, and improving patientsʼ mood, sleeping patterns and capacity to cope with disease. Examining the impact of integrative medicine on the side effects of cancer treatment would be beyond the scope of this review. This article therefore looks at short-term side effects of cancer treatment which are usually temporary and occur during or after local and systemic therapy. The focus is on mind-body medicine, acupuncture and classic naturopathic treatments developed by Sebastian Kneipp as complementary therapies. The latter includes hydrotherapy, phytotherapy, nutritional therapy, exercise therapy and a balanced lifestyle.
Zusammenfassung
Mit verbesserter Prognose und Fortschritten in der Diagnostik und Therapie des Mammakarzinoms rücken Aspekte wie Lebensqualität und Nebenwirkungsmanagement bei der Mammakarzinombehandlung in den Fokus der Ärzte und Therapeuten. Therapie- oder erkrankungsbedingte Nebenwirkungen mindern häufig die Lebensqualität und können damit zu einer zusätzlichen Beeinträchtigung der Patientin führen. Nicht selten sind Non-Compliance oder sogar Therapieabbruch die Folge. Studiendaten zeigen, dass durch Methoden der Integrativen Medizin therapie- und krankheitsbedingte Nebenwirkungen reduziert werden können. Eine Steigerung des Wohlbefindens und der Lebensqualität, der Abbau von Stressbelastungen und eine Verbesserung der Stimmung, des Schlafes und der Krankheitsbewältigung sind nachgewiesen. Alle Nebenwirkungen der Integrativen Medizin zu beleuchten, würde den Umfang des hier vorliegenden Reviews übersteigen, sodass sich dieser Artikel auf kurzfristige Nebenwirkungen, die in der Regel zeitlich begrenzt während oder nach der lokalen bzw. systemischen Therapie auftreten, fokussiert. Der Fokus richtet sich speziell auf Mind-Body-Medizin, Akupunktur und die klassischen Naturheilverfahren nach Sebastian Kneipp als integrative Therapieoptionen. Letztere umfassen die Hydrotherapie, Phytotherapie, Ernährungstherapie, Bewegungstherapie und Ordnungstherapie.
Key words
complementary and alternative medicine - CAM - integrative medicine - breast cancer - naturopathic treatment - phytotherapySchlüsselwörter
Komplementäre und Alternative Medizin - CAM - Integrative Medizin - Mammakarzinom - Naturheilverfahren - Phytotherapie-
References
- 1 Kreienberg R, Albert US, Follmann M et al. Interdisciplinary GoR level III guidelines for the diagnosis, therapy and follow-up care of breast cancer: short version – AWMF Registry No.: 032-045OL AWMF-Register-Nummer: 032-045OL – Kurzversion 3.0, Juli 2012. Geburtsh Frauenheilk 2013; 73: 556-583
- 2 Kommission Mamma der Arbeitsgemeinschaft Gynäkologische Onkologie e.V.. Diagnosis and Treatment of Patients with primary and metastatic Breast Cancer. München: W. Zuckschwerdt Verlag GmbH; 2013
- 3 Maass N, Schutz F, Fasching PA et al. Breast cancer update 2014 – focus on the patient and the tumour. Geburtsh Frauenheilk 2015; 75: 170-182
- 4 von Blanckenburg P, Schuricht F, Albert US et al. Optimizing expectations to prevent side effects and enhance quality of life in breast cancer patients undergoing endocrine therapy: study protocol of a randomized controlled trial. BMC Cancer 2013; 13: 426
- 5 Hall E, Cameron D, Waters R et al. Comparison of patient reported quality of life and impact of treatment side effects experienced with a taxane-containing regimen and standard anthracycline based chemotherapy for early breast cancer: 6 year results from the UK TACT trial (CRUK/01/001). Eur J Cancer 2014; 50: 2375-2389
- 6 Reinisch M, von Minckwitz G, Harbeck N et al. Side effects of standard adjuvant and neoadjuvant chemotherapy regimens according to age groups in primary breast cancer. Breast Care (Basel) 2013; 8: 60-66
- 7 Blanchette PS, Pritchard KI. Adjuvant endocrine therapy for breast cancer: longer therapy and the need for personalized treatment–should we treat beyond the data?. Oncology 2013; 27: 1230-1231
- 8 Bell RJ, Fradkin P, Schwarz M et al. Understanding discontinuation of oral adjuvant endocrine therapy by women with hormone receptor-positive invasive breast cancer nearly 4 years from diagnosis. Menopause 2013; 20: 15-21
- 9 Wuensch P, Hahne A, Haidinger R et al. Discontinuation and non-adherence to endocrine therapy in breast cancer patients: is lack of communication the decisive factor?. J Cancer Res Clin 2015; 141: 55-60
- 10 Chlebowski RT, Kim J, Haque R. Adherence to endocrine therapy in breast cancer adjuvant and prevention settings. Cancer Prev Res 2014; 7: 378-387
- 11 Huiart L, Ferdynus C, Giorgi R. A meta-regression analysis of the available data on adherence to adjuvant hormonal therapy in breast cancer: summarizing the data for clinicians. Breast Cancer Res Treat 2013; 138: 325-328
- 12 Murphy CC, Bartholomew LK, Carpentier MY et al. Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review. Breast Cancer Res Treat 2012; 134: 459-478
- 13 Fasching PA, Fehm T, Kellner S et al. Evaluation of therapy management and patient compliance in postmenopausal patients with hormone receptor-positive breast cancer receiving letrozole treatment: the EvaluateTM Study. Geburtsh Frauenheilk 2014; 74: 1137-1143
- 14 Rohrberg S. Quality of life and cosmetic output after breast-preserving therapy. Strahlenther Onkol 2007; 183: 104-105
- 15 Lux MP, Hack CC, Bani MR et al. Operative Therapiestrategien bei der Frau mit Mammakarzinom. Frauenheilkunde up2date 2012; 6: 73-95
- 16 Blaes AH, Kreitzer MJ, Torkelson C et al. Nonpharmacologic complementary therapies in symptom management for breast cancer survivors. Semin Oncol 2011; 38: 394-402
- 17 Casla S, Hojman P, Marquez-Rodas I et al. Running away from side effects: physical exercise as a complementary intervention for breast cancer patients. Clin Transl Oncol 2015; 17: 180-196
- 18 Finnegan-John J, Molassiotis A, Richardson A et al. A systematic review of complementary and alternative medicine interventions for the management of cancer-related fatigue. Integr Cancer Ther 2013; 12: 276-290
- 19 Fasching PA, Thiel F, Nicolaisen-Murmann K et al. Association of complementary methods with quality of life and life satisfaction in patients with gynecologic and breast malignancies. Support Care Cancer 2007; 15: 1277-1284
- 20 Molassiotis A, Browall M, Milovics L et al. Complementary and alternative medicine use in patients with gynecological cancers in Europe. Int J Gynecol Cancer 2006; 16 (Suppl. 01) 219-224
- 21 Shneerson C, Taskila T, Gale N et al. The effect of complementary and alternative medicine on the quality of life of cancer survivors: a systematic review and meta-analyses. Complement Ther Med 2013; 21: 417-429
- 22 Hüttner NBM, Hack CC, Hackl J et al. Klassische Naturheilverfahren nach Kneipp in der Gynäkologie und Geburtshilfe. Frauenheilkunde up2date 2014; 8: 95-113
- 23 Hack CC, Huttner NB, Fasching PA et al. Development and validation of a standardized questionnaire and standardized diary for use in integrative medicine consultations in gynecologic oncology. Geburtsh Frauenheilk 2015; 75: 377-383
- 24 Zainal NZ, Booth S, Huppert FA. The efficacy of mindfulness-based stress reduction on mental health of breast cancer patients: a meta-analysis. Psychooncology 2013; 22: 1457-1465
- 25 Cramer H, Lauche R, Paul A et al. Mindfulness-based stress reduction for breast cancer-a systematic review and meta-analysis. Curr Oncol 2012; 19: e343-e352
- 26 Lee A, Fan LT. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database Syst Rev 2009; (2) CD003281
- 27 Ezzo J, Richardson M, Vickers A et al. Acupuncture-point stimulation for chemotherapy-induced nausea or vomiting (Review). Cochrane Database Syst Rev 2010;
- 28 Posadzki P, Moon TW, Choi TY et al. Acupuncture for cancer-related fatigue: a systematic review of randomized clinical trials. Support Care Cancer 2013; 21: 2067-2073
- 29 Ryan JL, Heckler CE, Roscoe JA et al. Ginger (Zingiber officinale) reduces acute chemotherapy-induced nausea: a URCC CCOP study of 576 patients. Support Care Cancer 2012; 20: 1479-1489
- 30 Pommier P, Gomez F, Sunyach MP et al. Phase III randomized trial of Calendula officinalis compared with trolamine for the prevention of acute dermatitis during irradiation for breast cancer. J Clin Oncol 2004; 22: 1447-1453
- 31 Kwan ML, Cohn JC, Armer JM et al. Exercise in patients with lymphedema: a systematic review of the contemporary literature. J Cancer Surviv 2011; 5: 320-336
- 32 Cormie P, Pumpa K, Galvao DA et al. Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomised controlled trial. J Cancer Surviv 2013; 7: 413-424
- 33 Cassileth BR, Van Zee KJ, Yeung KS et al. Acupuncture in the treatment of upper-limb lymphedema: results of a pilot study. Cancer 2013; 119: 2455-2461
- 34 Wolff HH, Kieser M. Hamamelis in children with skin disorders and skin injuries: results of an observational study. Eur J Pediatr 2007; 166: 943-948
- 35 Martins MD, Marques MM, Bussadori SK et al. Comparative analysis between Chamomilla recutita and corticosteroids on wound healing. An in vitro and in vivo study. Phytother Res 2009; 23: 274-278
- 36 Reddy KK, Grossman L, Rogers GS. Common complementary and alternative therapies with potential use in dermatologic surgery: risks and benefits. J Am Acad Dermatol 2013; 68: e127-e135
- 37 Worthington HV, Clarkson JE, Bryan G et al. Interventions for preventing oral mucositis for patients with cancer receiving treatment. Cochrane Database Syst Rev 2011; (4) CD000978
- 38 Mansour G, Ouda S, Shaker A et al. Clinical efficacy of new aloe vera- and myrrh-based oral mucoadhesive gels in the management of minor recurrent aphthous stomatitis: a randomized, double-blind, vehicle-controlled study. J Oral Pathol Med 2014; 43: 405-409
- 39 Sahebjamee M, Mansourian A, Mohammad MH et al. Comparative efficacy of aloe vera and benzydamine mouthwashes on radiation-induced oral mucositis: a triple-blind, randomised, controlled clinical trial. Oral Health Prev Dent 2014;
- 40 Karaca H, Bozkurt O, Ozaslan E et al. Positive effects of oral beta-glucan on mucositis and leukopenia in colorectal cancer patients receiving adjuvant FOLFOX-4 combination chemotherapy. Asian Pac J Cancer Prev 2014; 15: 3641-3644
- 41 Suryakumar G, Gupta A. Medicinal and therapeutic potential of Sea buckthorn (Hippophae rhamnoides L.). J Ethnopharmacol 2011; 138: 268-278
- 42 Kraft K. Lehrbuch Naturheilverfahren. Stuttgart: Hippokrates; 2010
- 43 Beuth J. Evidence-based complementary oncology: innovative approaches to optimise standard therapy strategies. Anticancer Res 2010; 30: 1767-1771
- 44 Molassiotis A, Yung HP, Yam BM et al. The effectiveness of progressive muscle relaxation training in managing chemotherapy-induced nausea and vomiting in Chinese breast cancer patients: a randomised controlled trial. Support Care Cancer 2002; 10: 237-246
- 45 Kümmel S, Schütz F. Ernährung, körperliche Aktivität, komplementäre Therapiemaßnahmen und alternative Möglichkeiten zur Hormonersatztherapie nach Primärbehandlung eines Mammakarzinoms. Aktuelle Empfehlungen zur Prävention, Diagnostik und Therapie primärer und fortgeschrittener Mammakarzinome der AGO. 2013. Online: http://www.ago-online.de/fileadmin/downloads/leitlinien/mamma/2013_02_Februar/pdfs_D/2013D%252024_Komplementaere%2520Therapie.pdf
- 46 Vogler E, Brinkhaus B. Kursbuch Naturheilverfahren für die ärztliche Weiterbildung. München: Elsevier, Urban und Fischer; 2013
- 47 Beer A-M, Aber M. Leitfaden Naturheilverfahren für die ärztliche Praxis. München: Urban & Fischer; 2011
- 48 Marx WM, Teleni L, McCarthy AL et al. Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting: a systematic literature review. Nutr Rev 2013; 71: 245-254
- 49 Panahi Y, Saadat A, Sahebkar A et al. Effect of ginger on acute and delayed chemotherapy-induced nausea and vomiting: a pilot, randomized, open-label clinical trial. Integr Cancer Ther 2012; 11: 204-211
- 50 Herdegen T. Kurzlehrbuch Pharmakologie und Toxikologie. 2.. Aufl. Stuttgart: Thieme; 2014
- 51 Zick SM, Ruffin MT, Lee J et al. Phase II trial of encapsulated ginger as a treatment for chemotherapy-induced nausea and vomiting. Support Care Cancer 2009; 17: 563-572
- 52 Becker B, Kuhn U, Hardewig-Budny B. Double-blind, randomized evaluation of clinical efficacy and tolerability of an apple pectin-chamomile extract in children with unspecific diarrhea. Arzneimittelforschung 2006; 56: 387-393
- 53 Triplehorn C, Millard PS. A rice-based diet with green banana or pectin reduced diarrhea in infants better than a rice-alone diet. ACP J Club 2002; 136: 67
- 54 Attaluri A, Donahoe R, Valestin J et al. Randomised clinical trial: dried plums (prunes) vs. psyllium for constipation. Aliment Pharmacol Ther 2011; 33: 822-828
- 55 Ashraf W, Park F, Lof J et al. Effects of psyllium therapy on stool characteristics, colon transit and anorectal function in chronic idiopathic constipation. Aliment Pharmacol Ther 1995; 9: 639-647
- 56 Koebnick C, Wagner I, Leitzmann P et al. Probiotic beverage containing Lactobacillus casei Shirota improves gastrointestinal symptoms in patients with chronic constipation. Can J Gastroenterol 2003; 17: 655-659
- 57 Hackl J, Hüttner N, Hack C et al. Komplementäre Medizin: Beschwerden der Frau in verschiedenen Lebensphasen lindern. Frauenheilkunde up2date 2014; 2: 148-167