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Planta Med 2015; 81(15): 1345-1352
DOI: 10.1055/s-0035-1557820
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Diterpenoids from the Whole Plant of Lagochilus platyacanthus

Cheng-Gang Zhang   *
1   The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2   Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China
,
Lu Wang   *
3   Research Center for Health and Nutrition, Shanghai University of Traditional Chinese Medicine, Shanghai, China
,
Ye Lu
1   The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2   Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China
,
Zi Ye
1   The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2   Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China
,
Zhu-Zhen Han
1   The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2   Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China
,
Hong Xu
1   The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2   Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China
,
Gui-Xin Chou
1   The Ministry of Education (MOE) Key Laboratory for Standardization of Chinese Medicines, The State Administration of TCM (SATCM) Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Shanghai Key Laboratory of Complex Prescription, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai, China
2   Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai, China
› Author Affiliations
Further Information

Publication History

received 02 March 2015
revised 27 April 2015

accepted 30 June 2015

Publication Date:
26 August 2015 (online)

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Abstract

Five new diterpenoids, lagoditerpenes A–E (1–3, 5, 6), along with ten known compounds were isolated from the herb of Lagochilus platyacanthus. The absolute structures of 1–4 and 6 were unequivocally elucidated by extensive spectroscopic analyses in association with single-crystal X-ray diffraction, in which compounds 1 and 2 were the epimers at C-13. Furthermore, in in vitro assays, compounds 1, 2 and 6 showed moderate hemostatic activities by shortening the values of activated partial thromboplastin time.

Key words

Lagochilus platyacanthus - Lamiaceae - diterpenoids - hemostatic

* These authors contributed equally to this work.


Supporting Information

 

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