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Planta Med 2015; 81(15): 1345-1352
DOI: 10.1055/s-0035-1557820
DOI: 10.1055/s-0035-1557820
Natural Product Chemistry
Original Papers
Diterpenoids from the Whole Plant of Lagochilus platyacanthus
Further Information
Publication History
received 02 March 2015
revised 27 April 2015
accepted 30 June 2015
Publication Date:
26 August 2015 (online)
Abstract
Five new diterpenoids, lagoditerpenes A–E (1–3, 5, 6), along with ten known compounds were isolated from the herb of Lagochilus platyacanthus. The absolute structures of 1–4 and 6 were unequivocally elucidated by extensive spectroscopic analyses in association with single-crystal X-ray diffraction, in which compounds 1 and 2 were the epimers at C-13. Furthermore, in in vitro assays, compounds 1, 2 and 6 showed moderate hemostatic activities by shortening the values of activated partial thromboplastin time.
* These authors contributed equally to this work.
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