A New Microfluidic Phase-Transfer Reaction Using HPLC Guard Columns as the Reactor for the N³-Protection of Uridine Derivatives

Abstract

N³-Acylation of uridine derivatives with acyl chlorides, mediated by a phase-transfer reaction, was studied using a new microfluidic device containing an HPLC guard as an effective reactor. The acylated products were obtained in more than 80% yields in very short reaction times of several seconds.

Key words

microfluidic system - phase-transfer reaction - nucleoside chemistry - flow chemistry - HPLC guard column

• References and Notes

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