Synthesis of 8-Bromoflavone and Its Buchwald–Hartwig Reaction with Amines

Dedicated to the memory of Prof. Tamás Patonay

Abstract

Simple and convenient synthesis of 8-bromoflavone was achieved, starting from 2-bromophenol through 3′-bromo-2′-hydroxyacetophenone whose preparation was managed to be solved by optimized Fries rearrangement. The Buchwald–Hartwig reaction of 8-bromoflavone with different type of primary and secondary amines was carried out.

Key words

palladium - Buchwald–Hartwig reaction - flavones - catalysis - Fries rearrangement

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