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Synthesis 2016; 48(01): 97-102
DOI: 10.1055/s-0035-1560325
DOI: 10.1055/s-0035-1560325
paper
Synthesis of 8-Bromoflavone and Its Buchwald–Hartwig Reaction with Amines
Further Information
Publication History
Received: 29 July 2015
Accepted: 27 August 2015
Publication Date:
30 September 2015 (online)
Dedicated to the memory of Prof. Tamás Patonay
Abstract
Simple and convenient synthesis of 8-bromoflavone was achieved, starting from 2-bromophenol through 3′-bromo-2′-hydroxyacetophenone whose preparation was managed to be solved by optimized Fries rearrangement. The Buchwald–Hartwig reaction of 8-bromoflavone with different type of primary and secondary amines was carried out.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560325.
- Supporting Information
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