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DOI: 10.1055/s-0035-1560354
Combined Asymmetric Aminocatalysis and Carbene Catalysis
Publikationsverlauf
Received: 19. August 2015
Accepted after revision: 17. September 2015
Publikationsdatum:
15. Oktober 2015 (online)
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Abstract
The use of multiple catalytic systems for cascade reactions has found widespread application in recent years. The combination of two important organocatalysts, chiral amines and N-heterocyclic carbenes (NHCs), is of extraordinary interest since they can both potentially mediate a variety of reactions with aldehyde derivatives. In this short review, we discuss the successful combination of asymmetric aminocatalysis and carbene catalysis in the efficient construction of complex chiral architectures, either in a relay or sequential manner.
1 Introduction
2 NHC-Catalyzed Redox Reaction Combined with Aminocatalysis
3 NHC-Catalyzed Benzoin Condensation Combined with Aminocatalysis
4 NHC-Catalyzed Stetter reaction Combined with Aminocatalysis
5 Miscellaneous NHC Catalysis Combined with Aminocatalysis
6 Summary
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For selected reviews, see:
For reviews on aminocatalysis, see:
For examples of combined catalysis of tertiary amine and NHC, see:
For reviews, see:
For reviews, see:
Only activated ketimines have been utilized in aza-benzoin reactions with limited examples; see:
Under basic conditions, the α-hydroxy ketone would easily form an anion intermediate and be oxidized to dicarbonyl co-products:
For recent reviews on new types of NHC-catalyzed reactions, see:
For selected examples, see: