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Synthesis 2015; 47(24): 3901-3906
DOI: 10.1055/s-0035-1560480
DOI: 10.1055/s-0035-1560480
paper
Clean and Efficient Iodination of Thiophene Derivatives
Further Information
Publication History
Received: 26 June 2015
Accepted after revision: 26 August 2015
Publication Date:
11 September 2015 (online)
![](https://www.thieme-connect.de/media/synthesis/201524/lookinside/thumbnails/ss-2015-z0402-op_10-1055_s-0035-1560480-1.jpg)
Abstract
Iodination of thiophene derivatives is realized using a simple, fast, and efficient methodology. Iodination of thiophene and 2- or 3-substituted or 3,4-disubstituted thiophenes with N-iodosuccinimide (NIS) activated with 4-toluenesulfonic acid in ethanol gives pure iodinated products that require no further purification.
Key words
iodination - thiophene - green methodology - regioselectivity - 4-toluenesulfonic acid - catalysisSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1560480.
- Supporting Information
Primary Data
- Primary data for this article are available online at http://www.thieme-connect.com/products/ejournals/journal/10.1055/s-00000084 and can be cited using the following DOI: 10.4125/pd0071th.
- Primary Data
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