Synlett 2015; 26(18): 2598-2600
DOI: 10.1055/s-0035-1560634
letter
© Georg Thieme Verlag Stuttgart · New York

One-Pot Synthesis of Isoquinolin-1(2H)-ones by a Sequential Ugi 4CC/Wittig Process

Zhuan Duan
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China   eMail: mwding@mail.ccnu.edu.cn
,
Yun Gao
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China   eMail: mwding@mail.ccnu.edu.cn
,
Ding Yuan
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China   eMail: mwding@mail.ccnu.edu.cn
,
Ming-Wu Ding*
Key Laboratory of Pesticide and Chemical Biology of Ministry of Education, Central China Normal University, Wuhan 430079, P. R. of China   eMail: mwding@mail.ccnu.edu.cn
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Publikationsverlauf

Received: 13. Juli 2015

Accepted after revision: 27. August 2015

Publikationsdatum:
23. September 2015 (online)


Abstract

A one-pot synthetic approach to isoquinolin-1(2H)-ones through a Ugi/Wittig sequence has been developed. The reaction of phosphonium salt, aldehyde, secondary amine, and isocyanide produced isoquinolin-1(2H)-ones in good yields through sequential Ugi condensation and intramolecular Wittig reaction in the presence of K2CO3.

Supporting Information