Polyfunctional Zinc and Magnesium Organometallics for Organic Synthesis: Some Perspectives

Abstract

The most important methods for the preparation of polyfunctional Zn and Mg reagents are highlighted. New perspectives for increasing the synthetic potential of these reagents including the use of Lewis acid catalysis, in situ trapping reactions, continuous flow conditions, and solid, air-stable zinc organometallics are described.

1 Introduction

2 Preparation Methods

3 Air-Stable Solid Organozinc Reagents

4 Lewis Acid Catalyst Compatibility with Polyfunctional Zinc and Magnesium Organometallics

5 Metalations in Flow Mode

6 Conclusion

Key words

zinc - magnesium - lithium chloride - flow chemistry - Lewis acids

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• 30 Reactions were typically carried out in coiled reactors and tubes (1.0 mm id; 0.2–20 mL volume) made from PFA, PTFE Teflon or stainless steel.
• 31 Reactions were typically conducted on a 1.5 mmol scale. These flow reactions can be readily scaled up to a 10 mmol scale.