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Synthesis 2016; 48(08): 1101-1107
DOI: 10.1055/s-0035-1561198
DOI: 10.1055/s-0035-1561198
short review
Polyfunctional Zinc and Magnesium Organometallics for Organic Synthesis: Some Perspectives
Further Information
Publication History
Received: 26 November 2015
Accepted after revision: 21 December 2015
Publication Date:
18 January 2016 (online)
Abstract
The most important methods for the preparation of polyfunctional Zn and Mg reagents are highlighted. New perspectives for increasing the synthetic potential of these reagents including the use of Lewis acid catalysis, in situ trapping reactions, continuous flow conditions, and solid, air-stable zinc organometallics are described.
1 Introduction
2 Preparation Methods
3 Air-Stable Solid Organozinc Reagents
4 Lewis Acid Catalyst Compatibility with Polyfunctional Zinc and Magnesium Organometallics
5 Metalations in Flow Mode
6 Conclusion
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- 30 Reactions were typically carried out in coiled reactors and tubes (1.0 mm id; 0.2–20 mL volume) made from PFA, PTFE Teflon or stainless steel.
- 31 Reactions were typically conducted on a 1.5 mmol scale. These flow reactions can be readily scaled up to a 10 mmol scale.