Hydrazine in the Ugi Tetrazole Reaction

^◊� The authors contributed equally to the work.

Abstract

We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-step procedure is given.

Key words

hydrazine - isocyanides - tetrazoles - multicomponent reaction - Ugi reaction

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