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Synthesis 2016; 48(08): 1122-1130
DOI: 10.1055/s-0035-1561353
DOI: 10.1055/s-0035-1561353
paper
Hydrazine in the Ugi Tetrazole Reaction
Further Information
Publication History
Received: 25 November 2015
Accepted after revision: 08 January 2016
Publication Date:
15 February 2016 (online)
◊� The authors contributed equally to the work.
Abstract
We describe the hitherto unknown use of N-Boc-protected hydrazine in the Ugi tetrazole reaction to access a library of highly substituted 5-(hydrazinomethyl)-1-methyl-1H-tetrazoles. The reaction is very versatile and good to high yielding. A one-pot, two-step procedure is given.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1561353x.
- Supporting Information
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